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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
Published on: January 11, 2020
Predictive validity and diagnostic stability of mild cognitive impairment subtypes
Ji Won Han1, Tae Hui Kim, Seok Bum Lee
1Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gyeonggido, Korea.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|October 30, 2012
Summary
Mild cognitive impairment (MCI) subtypes based on multiple impaired domains predict worse outcomes than single-domain MCI. However, MCI subtypes are diagnostically unstable, with frequent shifts between categories over time.
Area of Science:
- Neurology
- Gerontology
- Cognitive Science
Background:
- Mild cognitive impairment (MCI) is classified into subtypes based on memory impairment and the number of affected cognitive domains.
- The predictive validity and diagnostic stability of these MCI subtypes are not well-established.
Purpose of the Study:
- To evaluate the predictive validity of MCI subtypes for clinical outcomes.
- To assess the diagnostic stability of MCI subtypes over an 18-month follow-up period.
Main Methods:
- Analysis of 140 MCI patients from the Korean Longitudinal Study on Health and Aging with 18-month follow-up.
- Multinomial logistic regression used to assess predictive validity of MCI subtypes.
- Annual conversion rates calculated to determine diagnostic stability between subtypes.
Main Results:
- Multiple-domain MCI (MCIm) showed significantly lower reversion to normal cognition (10.94%) and higher conversion to dementia (23.44%) compared to single-domain MCI (MCIs) (43.42% reversion, 5.26% dementia conversion).
- No significant differences in reversion or conversion rates were found between amnestic and nonamnestic MCI subtypes.
- Among participants without conversion or reversion, 17.74% annually converted to a different MCI subtype.
Conclusions:
- The number of impaired cognitive domains, not memory impairment, is a key predictor of poor outcomes in MCI.
- MCI subtypes demonstrate significant diagnostic instability, with frequent transitions between categories.
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