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Updated: May 17, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Can we deconstruct cancer, one patient at a time?
C Anthony Blau1, Effie Liakopoulou
1Department of Medicine/Hematology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. tblau@uw.edu
Bridging the gap between cancer research and clinical practice requires learning loops. Engaging patients as partners in a distributed network accelerates knowledge transfer for better cancer understanding.
Area of Science:
- Oncology
- Translational Medicine
- Bioinformatics
Background:
- The rapid advancement of medical technology outpaces its integration into clinical cancer care.
- A significant gap exists in translating laboratory discoveries into practical patient treatments.
- Current research models often lack direct, rapid feedback from patient outcomes.
Purpose of the Study:
- To propose a novel framework for a distributed research network connecting patients, oncologists, and advanced resources.
- To facilitate the immediate transfer of knowledge between clinical practice and laboratory research.
- To leverage intensive patient monitoring for a deeper collective understanding of cancer biology.
Main Methods:
- Establishing a distributed network infrastructure to link select cancer patients with world-class research resources.
- Implementing intensive monitoring of individual patient experiences and treatment responses.
- Creating learning loops for real-time data sharing and analysis between clinical and research settings.
Main Results:
- The proposed network aims to accelerate the translation of technological advancements into clinical cancer care.
- Intensive monitoring of patient data will provide real-world evidence for cancer research.
- Engaging patients as active partners fosters a collaborative approach to cancer discovery.
Conclusions:
- A distributed network model can effectively bridge the lab-clinic gap in cancer research.
- Direct patient involvement and real-time data are crucial for advancing cancer understanding.
- This approach promises to enhance the pace and relevance of cancer treatment innovation.
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