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Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

Overview
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...

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Related Experiment Video

Updated: May 17, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

[Osteoimmunology-overview].

Kazuo Okamoto1, Hiroshi Takayanagi

  • 1Department of Immunology, The University of Tokyo, Takayanagi, Japan.

Clinical Calcium
|October 30, 2012
PubMed
Summary
This summary is machine-generated.

The immune and skeletal systems interact, influencing bone health. Osteoimmunology research reveals how immune cells like Th17 cells impact bone destruction in rheumatoid arthritis (RA).

Related Experiment Videos

Last Updated: May 17, 2026

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

Area of Science:

  • Osteoimmunology
  • Immunology
  • Skeletal Biology

Context:

  • The immune and skeletal systems share regulatory molecules, notably cytokines.
  • Studies on rheumatoid arthritis (RA)-associated bone destruction and immune-compromised mouse models highlight the critical interplay between these systems.
  • This interaction has fostered the interdisciplinary field of osteoimmunology.

Purpose:

  • To explore the intricate relationship between the immune and skeletal systems.
  • To elucidate the mechanisms underlying bone destruction in RA, particularly the role of Th17 cells.
  • To investigate the bidirectional communication between bone cells and hematopoietic stem cells in bone marrow.

Summary:

  • Bone destruction in RA is linked to heightened osteoclast activity, driven by activated Th17 cells.
  • Bone marrow harbors diverse cell types that mutually regulate bone homeostasis, calcium metabolism, and hematopoiesis.
  • Osteoimmunology provides a crucial framework for understanding these complex interactions.

Impact:

  • Osteoimmunological insights are increasingly vital for clinical applications in rheumatology and bone diseases.
  • This field is essential for advancing research in both bone and mineral metabolism and immunology.
  • Understanding these interactions may lead to novel therapeutic strategies for immune-mediated bone disorders.