Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 17, 2026

Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall

Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall

Published on: July 31, 2015

Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.

Gregory D Scott¹, Allison D Fryer, David B Jacoby

¹Division of Pulmonary and Critical Care, Oregon Health and Sciences University, Portland, OR 97239-3098, USA.

American Journal of Respiratory Cell and Molecular Biology

|October 30, 2012

Summary

This study introduces a computational method for precise airway nerve quantification, overcoming challenges posed by sparse nerve distribution. This approach enhances the measurement of peripheral neuroplasticity in lung development and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Optogenetic vagotomy inhibits reflex bronchoconstriction and cardiac chronotropy.

American journal of respiratory cell and molecular biology·2026

Same author

Interleukin 6 Drives Durable T Cell-Mediated Immunity to Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology·2026

Same author

Heavy Moms, Wheezy Kids: How Maternal Obesity Harms Breathing in Offspring.

American journal of respiratory cell and molecular biology·2026

Same author

Small Strokes, Big Impact: Excessive Mortality After Acute Ischemic Stroke in Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society·2026

Same author

Obstructive Sleep Apnea, Positive Airway Pressure, and Implications of Early Treatment in Parkinson Disease.

JAMA neurology·2025

Same author

Eosinophil peroxidase induces inflammation in a mouse model of dermatitis.

Journal of leukocyte biology·2025

Area of Science:

Pulmonary medicine
Neuroscience
Computational pathology

Background:

Quantitative histological analysis of airway innervation is difficult due to sparse and patchy nerve distribution.
Accurate nerve quantification is crucial for understanding lung development and disease-related neuroplasticity.

Purpose of the Study:

To develop and validate a computational approach for precise measurement of airway nerve architecture.
To enable more complete nerve quantification and assess peripheral neuroplasticity.

Main Methods:

Development of a computer-based analysis tool for quantifying three-dimensional (3D) nerve architecture.
Comparison of computational analysis with manual scoring for accuracy in measuring nerve branchpoints and lengths.
Application of the method to murine lung tissue and human bronchoscopic biopsies.

More Related Videos

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

Related Experiment Videos

Last Updated: May 17, 2026

Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall

Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall

Published on: July 31, 2015

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

In Vivo Morphometric Analysis of Human Cranial Nerves Using Magnetic Resonance Imaging in Menière's Disease Ears and Normal Hearing Ears

Published on: February 21, 2018

Main Results:

The computational approach significantly outperforms manual scoring in quantifying 3D nerve branchpoints and lengths.
Previously unidentified airway epithelial nerves were detected in murine lungs due to the method's sensitivity.
The approach successfully quantified 3D nerve morphology in various human tissues, including airways, esophagus, colon, and skin.

Conclusions:

This computational method offers a robust solution for accurate airway nerve quantification.
The approach facilitates the study of structural peripheral neuroplasticity in lung development and disease.
The validated method has broad applicability across different tissues for nerve architecture analysis.