Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: 5-HT₃ Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

Local Anesthetics: Clinical Application as Epidural Anesthesia

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates these...

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Is trunk motion influenced by breast volume? The effect on joint moments at the hip, knee and ankle.

Journal of science and medicine in sport·2026

Same author

What Is the Effect of Breast Size on Running Economy and Upper Body Biomechanical Factors Contributing to Running Economy?

Medicine and science in sports and exercise·2025

Same author

Tramadol, breast feeding and safety in the newborn.

Archives of disease in childhood·2018

Same author

Implication of Major Adverse Postoperative Events and Myocardial Injury on Disability and Survival: A Planned Subanalysis of the ENIGMA-II Trial.

Anesthesia and analgesia·2018

Same author

Survival After Isolated Post-Operative Troponin Elevation.

Journal of the American College of Cardiology·2017

Same author

A randomised crossover trial comparing the Airtraq(®) NT, McGrath(®) MAC and Macintosh laryngoscopes for nasotracheal intubation of simulated easy and difficult airways in a manikin.

Brazilian journal of anesthesiology (Elsevier)·2016

Search research articles

Related Experiment Video

Updated: May 17, 2026

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Published on: January 31, 2025

Prophylactic ondansetron does not prevent shivering or decrease shivering severity during cesarean delivery under

Roger M Browning¹, William H Fellingham, Edmond J O'Loughlin

¹Department of Anaesthesia and Pain Medicine, Fremantle Hospital, Western Australia, Australia. roger.browning@health.wa.gov.au

Regional Anesthesia and Pain Medicine

|October 30, 2012

Summary

Ondansetron did not reduce shivering during cesarean delivery anesthesia. This study found no significant difference in shivering incidence or severity between ondansetron and placebo groups.

Related Experiment Videos

Last Updated: May 17, 2026

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Spinal Sonography for Ultrasound-Guided Lumbar Neuraxial Anesthesia

Published on: January 31, 2025

Area of Science:

Anesthesiology
Obstetrics
Pharmacology

Background:

Maternal shivering is a common side effect of regional anesthesia during cesarean delivery.
Shivering can cause patient distress and complicate monitoring.
Ondansetron is known to reduce shivering in nonobstetric patients.

Purpose of the Study:

To evaluate the antishivering efficacy of ondansetron in women undergoing cesarean delivery.
To determine if intravenous ondansetron 8 mg reduces the incidence or severity of shivering compared to placebo before combined spinal epidural anesthesia.

Main Methods:

A randomized, double-blinded, placebo-controlled trial involving 118 women scheduled for elective cesarean surgery.
Participants received either intravenous ondansetron 8 mg or saline before combined spinal epidural anesthesia.
Shivering incidence and severity were assessed using a 5-point scale at multiple time points.

Main Results:

No significant difference in the overall incidence of shivering between the ondansetron group (41%) and the placebo group (47%).
No significant difference in the incidence of severe shivering between the groups (ondansetron 32% vs. placebo 33%).
No significant differences were observed for secondary outcomes like nausea, pruritus, or headache.

Conclusions:

Intravenous ondansetron 8 mg administered before combined spinal epidural anesthesia does not effectively decrease the incidence or severity of shivering in women undergoing cesarean delivery.
The findings suggest ondansetron is not an effective prophylactic treatment for shivering in this specific patient population.