Related Experiment Video
Updated: May 17, 2026
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Serum apolipoproteins in the patients of myocardial infarction in different age groups
Insights
Serum Apo A-1 and Apo-B levels are better indicators of coronary artery disease risk than traditional lipid profiles in myocardial infarction survivors. These apolipoproteins show significant changes post-infarction.
Area of Science:
- Cardiology
- Biochemistry
- Lipid Metabolism
Background:
- Myocardial infarction (MI) survivors often exhibit altered lipid profiles.
- Traditional lipid parameters like cholesterol and HDLc may not fully capture cardiovascular risk post-MI.
Purpose of the Study:
- To evaluate serum lipid and apolipoprotein levels in MI survivors.
- To determine if apolipoproteins are superior markers for coronary artery disease (CAD) compared to standard lipids.
Main Methods:
- Analysis of serum cholesterol (Ch), HDLc, LDLc, VLDLc, Triglyceride (Tg), Apolipoprotein A-1 (Apo A-1), and Apolipoprotein B (Apo B) in 151 MI survivors.
- Comparison of these markers across different age groups.
Main Results:
- Significant increases observed in triglyceride, LDLc, and Apo B levels.
- Significant decreases noted in Apo A-1 levels and the Apo A-1/B ratio.
- No significant alterations in total cholesterol or VLDLc, with exceptions in specific age groups for HDLc.
Conclusions:
- Serum Apo A-1 and Apo B demonstrate significant alterations in MI survivors.
- Apolipoproteins may serve as more sensitive biomarkers for CAD than traditional lipid parameters.
Abstract:
The level of serum cholesterol (Ch), serum-high density lipoprotein cholesterol (HDLc), serum-low density lipoprotein cholesterol (LDLc), serum very low density lipoprotein cholesterol (VLDLc), Triglyceride (Tg), Apolipoprotein A-1, B and ratio of Apolipoprotein A1/B were observed in 151 survivors of myocardial infarction in different age groups. A significant increase was found in the level of triglyceride, LDLc, apolipoprotein-B and a significant decrease in apolipoprotein-A1 and the ratio of apolipoprotein A1/B. No significant alteration was found in serum cholesterol, HDLc except in the age group of 31-40 years and 41-50 years and VLDLc. Thus, serum Apo A-1 and Apo-B may be considerably better markers for coronary artery disease than traditional lipid parameters.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:26Atherosclerosis III: Management
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:30Coronary Artery Disease III: Clinical Manifestations
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...