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Graves Disease II: Pathophysiology

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Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

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Hyperthyroidism I: Introduction

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Updated: May 17, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Serum creatine phosphokinase in thyroid disorders.

Rashmi Ranka¹, Rati Mathur

¹Department of Biochemistry, J.L.N. Medical College, 305001 Ajmer, Raj.

Indian Journal of Clinical Biochemistry : IJCB

|October 30, 2012

Summary

Serum creatine phosphokinase (CPK) levels inversely correlate with thyroid hormones. Hypothyroid patients showed elevated CPK with low triiodothyronine (T3) and thyroxine (T4), while hyperthyroid patients had decreased CPK with high T3 and T4.

Keywords:

Creatine phosphokinase (CPK)Hypothyroidism Triiodothyronine (T3)

Related Experiment Videos

Last Updated: May 17, 2026

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Area of Science:

Endocrinology
Clinical Biochemistry

Background:

Decreased serum triiodothyronine (T3) and thyroxine (T4) are established in hypothyroidism.
The relationship between creatine phosphokinase (CPK) and thyroid dysfunction requires further investigation.

Purpose of the Study:

To investigate the correlation between serum CPK levels and thyroid profiles in patients with thyroid diseases.
To determine the relationship between CPK and thyroid hormones (T3, T4) and thyroid-stimulating hormone (TSH).

Main Methods:

Serum samples were analyzed for T3, T4, TSH, and CPK levels.
Patients with hypothyroidism and hyperthyroidism were included in the study.

Main Results:

Hypothyroid patients exhibited lower T3 and T4 levels, elevated TSH, and significantly increased serum CPK.
Hyperthyroid patients showed higher T3 and T4 levels, decreased TSH, and significantly reduced serum CPK.
Serum CPK levels demonstrated an inverse relationship with serum T3 and T4 levels.

Conclusions:

Serum CPK levels are inversely correlated with serum T3 and T4 levels.
CPK can serve as a potential biomarker for assessing thyroid status.