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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Biochemical markers for alcohol consumption.

Subir Kumar Das¹, Prasunpriya Nayak, D M Vasudevan

¹Department of Biochemistry, Sikkim Manipal Institute of Medical Sciences, 5th Mile, Tadong, 737 102 Gangtok, Sikkim India.

Indian Journal of Clinical Biochemistry : IJCB

|October 30, 2012

Summary

This summary is machine-generated.

Laboratory tests aid in diagnosing alcohol use disorders, with established markers like GGT and MCV reflecting intake. Emerging biomarkers offer potential for more sensitive and specific detection of alcohol consumption.

Keywords:

Alcohol Aminotransferase Biochemical marker Carbohydrate deficient transferrin γ-Glutamyltransferase

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Area of Science:

Clinical Biochemistry
Toxicology
Internal Medicine

Background:

Laboratory tests are crucial for diagnosing alcohol consumption and related disorders, especially when patient history is unreliable.
Established biochemical and hematological markers, including gamma-glutamyltransferase (GGT) and mean corpuscular volume (MCV), correlate with alcohol intake.
These markers are valuable for prognosis and assessing hazardous alcohol consumption.

Purpose of the Study:

To review established and emerging laboratory markers for diagnosing alcohol consumption.
To highlight the utility of these tests in clinical settings and for monitoring alcohol intake.
To discuss the potential of novel biomarkers for improved diagnostic accuracy.

Main Methods:

Review of established biochemical and hematological tests used as markers of alcohol intake.
Discussion of established markers such as gamma-glutamyltransferase (GGT) activity, aspartate aminotransferase (AST) activity, high-density lipoprotein cholesterol (HDL-C), and erythrocyte mean corpuscular volume (MCV).
Exploration of emerging markers including carbohydrate deficient transferrin, β-hexosaminidase, acetaldehyde adducts, and urinary serotonin metabolite ratios.

Main Results:

Established markers like GGT, AST, HDL-C, and MCV show correlations with alcohol intake and decrease upon abstinence.
These tests provide prognostic information and are integral to assessing hazardous alcohol consumption.
Emerging markers demonstrate potential for more accurate and sensitive reflection of recent alcohol intake.

Conclusions:

Established laboratory tests are valuable tools for assessing alcohol consumption and providing prognostic information.
Novel biomarkers like carbohydrate deficient transferrin and others hold promise for enhancing diagnostic sensitivity and specificity.
Continued research into these markers can lead to improved monitoring of alcohol intake.