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Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
Published on: February 21, 2016
Comparative ultrastructure of subsurface cisternae in inner and outer hair cells of the guinea pig cochlea
1Department of Communication and Neuroscience, University of Keele, England.
Abstract:
The subsurface cisternal systems of outer hair cells (OHCs) from different cochlear regions have been compared with the subsurface cisternal system of inner hair cells. Three main observations have been made: (1) the number of cisternal layers, when there is more than one present, is reduced along the length of an individual outer hair cell; (2) basal outer hair cells may have only one fenestrated cisternal layer; and (3) the inner hair cells possess a lateral cistern and associated pillar and filament complexes which are very similar to those of some basal OHCs. These observations are discussed in relation to hypotheses regarding the role of these structures in hair cell motility.
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