Changes in serum ceruloplasmin levels with commonly used methods of contraception

It is a well established fact that long term use of oral contraceptives is hazardous to health. The most common methods of contraception used by women in reproductive age group include use of oral contraceptives and copper «T». One of the causative factors for the side effects of the «pill» is presumed to be increase in serum cereloplasmin levels which has pro-oxidant activity. The present study involves the study of serum ceruloplasmin levels in two groups of subjects i.e. 30 women using oral contraceptive and 30 women using copper «T». 30 healthy females in reproductive age group were chosen as controls. It was observed that oral contraceptives increase the serum ceruloplasmin levels (p < 0.001) and the difference is highly significant as compared to no change (p < 0.1) in the groups using copper «T» as contraceptives.