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Published on: July 3, 2018

Homocysteine status and acute myocardial infarction among Tamilians

T Angeline1, Rita Mary Aruna, K Ramadevi

  • 1Department of Zoology, Lady Doak College, Madurai, Tamil Nadu India.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

Elevated plasma homocysteine levels are significantly associated with acute myocardial infarction in Tamil patients. This finding suggests hyperhomocysteinemia may be a crucial risk factor for heart attacks.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Myocardial infarction is a primary complication of coronary artery disease.
  • Emerging evidence suggests hyperhomocysteinemia as a potential contributor to myocardial infarction.
  • Traditional risk factors do not fully explain all cases of myocardial infarction.

Purpose of the Study:

  • To investigate the association between plasma homocysteine levels and acute myocardial infarction.
  • To determine if hyperhomocysteinemia is a significant risk factor in the Tamil population.

Main Methods:

  • Plasma homocysteine concentrations were measured in 60 patients with acute myocardial infarction.
  • Plasma homocysteine levels were also measured in 35 age-matched healthy controls.
  • Statistical analysis was performed to compare homocysteine levels between the two groups.

Main Results:

  • Mean plasma homocysteine levels were significantly higher in myocardial infarction patients (24.59±6.14 mM/L) compared to healthy controls (13.73 ±3.54 mM/L).
  • The difference in homocysteine concentrations between patients and controls was statistically significant (p<0.01).

Conclusions:

  • A strong association exists between elevated plasma homocysteine and acute myocardial infarction in the Tamil population.
  • Plasma homocysteine is indicated as a potential risk factor for myocardial infarction.
  • Further research is warranted to explore the clinical implications of hyperhomocysteinemia in cardiovascular disease.

Keywords:
Acute myocardial infarctionHyperhomocysteinemiaProaggregant

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