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Risk factors for coronary heart disease in type II diabetes mellitus

H Surekha Rani1, G Madhavi, V Ramachandra Rao

  • 1Dept. of Cell Biology, Institute of Genetics amd Hospital for Genetic Diseases, Osmania University, Begumpet, 16 Hyderabad.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

Diabetic patients with type II diabetes exhibit elevated oxidative stress markers and reduced antioxidant capacity, increasing their risk for coronary heart disease. Assessing these factors is crucial for preventing cardiovascular complications.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Cardiovascular complications are a leading cause of death in diabetic patients.
  • Type II diabetes is associated with an increased risk of coronary heart disease.

Purpose of the Study:

  • To evaluate the risk factors for coronary heart disease in type II diabetics.
  • To assess markers of oxidative stress and antioxidant capacity in type II diabetics.

Main Methods:

  • Comparison of fasting and postprandial plasma glucose, lipid profiles (total cholesterol, LDL, triglycerides, HDL), malondialdehyde, nitrite/nitrate, and total antioxidant status between type II diabetics and control groups.

Main Results:

  • Type II diabetics showed higher levels of plasma glucose, total cholesterol, LDL, triglycerides, malondialdehyde, and nitrite/nitrate compared to controls.
  • Type II diabetics had lower levels of HDL and total antioxidant status compared to controls.

Conclusions:

  • Diabetic patients exhibit increased oxidative stress and diminished antioxidant capacity, contributing to coronary heart disease risk.
  • Routine assessment of oxidative stress markers and antioxidant status is recommended for diabetic patients.
  • Antioxidant therapy, alongside preventive measures, may mitigate cardiovascular complications in type II diabetes.

Keywords:
Coronary Heart DiseaseOxidative stressRisk factorsTotal antioxidant statusType II Diabetes Mellitus

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