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Effect ofVitex negundo leaf extract on the free radicals scavengers in complete Freund's adjuvant induced arthritic
P Renuka Devi1, S Krishna Kumari, C Kokilavani
1Department of Biochemistry, Kovai Kalaimagal College of Arts and Science, Narasipuram, 641 109 Coimpatore, TamilNadu India.
Abstract:
The effect of the oral administration ofVitex negundo leaf extract on the levels of enzymic and non-enzymic antioxidants were studied in the adjuvant induced arthritic (AIA) rats The levels of antioxidant enzymes such as SOD, CAT, GPx, G6PD, GSH and Vit-C were estimated in various groups of the experimental rats. It was observed that the antioxidant enzyme levels in the AIA were significantly low when compared to normal rats. A significant decrease in enzymic antioxidant-SOD, CAT, GPx, G6PD and non-enzymic antioxidant-GSH, Vit-C were observed in the liver of AIA rats compared to the normal rats. These results suggest that the leaf extract ofVitex negundo possesses antioxidant activity.
