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Glycemic control modifies the association between microalbuminuria and c-reactive protein in Type 2 Diabetes Mellitus

Kaushik Bhowmick1, A V M Kutty, H V Shetty

  • 1Department of Biochemistry, Sri Devaraj Urs Medical College and R.L. Jalappa Hospital, Tamaka, Kolar, 563 101 Karnataka.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

In Type 2 Diabetes Mellitus, elevated C-reactive protein correlates with microalbuminuria in patients with poor glycemic control, indicating inflammation. Glycemic control is crucial for managing this association and preventing diabetic complications.

Area of Science:

  • Endocrinology
  • Nephrology
  • Cardiovascular Medicine

Background:

  • Microalbuminuria and C-reactive protein are linked to disease processes.
  • Type 2 Diabetes Mellitus (T2DM) management involves monitoring glycemic control.
  • Inflammation and endothelial dysfunction are implicated in diabetic complications.

Purpose of the Study:

  • To investigate the association between C-reactive protein (CRP) and microalbuminuria in T2DM patients.
  • To compare these associations based on glycemic control (poor vs. adequate).
  • To explore the role of inflammation in the pathogenesis of microalbuminuria in T2DM.

Main Methods:

  • Cross-sectional study design.
  • Inclusion of T2DM patients categorized by glycemic control.
  • Measurement of microalbuminuria and C-reactive protein levels.

Main Results:

  • Significant positive correlation between CRP and microalbuminuria in T2DM patients with poor glycemic control.
  • Higher prevalence of microalbuminuria at elevated CRP levels in poorly controlled diabetics.
  • No significant association found in patients with adequate glycemic control.
  • Increased microalbuminuria levels in poorly controlled vs. well-controlled diabetics at comparable CRP levels.

Conclusions:

  • Endothelial dysfunction and inflammation are key in microalbuminuria pathogenesis in T2DM.
  • Glycemic control significantly influences the progression of inflammation and microalbuminuria.
  • Monitoring CRP and microalbuminuria may aid in risk stratification for T2DM complications.
Keywords:
C-reactive proteinDiabetes MellitusGlycemic controlMicroalbuminuria

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