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Related Experiment Video

Updated: May 17, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Alcohol induced effects on kidney.

Subir Das Kumar¹, D M Vasudevan

¹Department of Biochemistry, Amrita Institute of Medical Sciences, Elamakkara P.O., Cochin, 682026 Kerala India.

Indian Journal of Clinical Biochemistry : IJCB

|October 30, 2012

Summary

Chronic ethanol consumption harms kidney function by reducing tubular reabsorption and increasing oxidative stress. Antioxidants like polyphenols may protect kidneys from ethanol-induced damage.

Keywords:

Alcohol Electrolyte Kidney Oxidative stress Renal function

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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Assessment of Glutamine as a Fuel Source for Alveolar Macrophages Exposed to Chronic Ethanol Using an Extracellular Flux Bioanalyzer

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Published on: November 15, 2024

Area of Science:

Nephrology
Toxicology
Biochemistry

Background:

Ethanol and its metabolites are primarily excreted via the kidneys.
Chronic ethanol intake impairs renal tubular reabsorption and overall kidney function.
Kidney vulnerability to oxidative damage is linked to high polyunsaturated fatty acid content.

Purpose of the Study:

To investigate the impact of chronic ethanol administration on renal function and structure.
To explore the role of oxidative stress and lipid peroxidation in ethanol-induced nephrotoxicity.
To assess the potential protective effects of antioxidants, such as polyphenols.

Main Methods:

Analysis of ethanol and metabolite levels in urine, blood, and liver.
Assessment of renal tubular reabsorption and function.
Evaluation of kidney membrane composition and lipid peroxidation markers.
Histopathological examination of renal ultra structure.

Main Results:

Ethanol concentration is higher in urine than in blood or liver post-administration.
Chronic ethanol intake leads to decreased renal tubular reabsorption and reduced renal function.
Ethanol exposure causes renal ultra structural abnormalities and increases oxidative stress.

Conclusions:

Chronic ethanol consumption significantly impairs kidney function through mechanisms involving oxidative stress and altered membrane composition.
Polyphenols show promise in mitigating ethanol-induced kidney damage by reducing oxidative vulnerability.