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Oxidative stress and disturbance in antioxidant balance in beta thalassemia major

Rahul A Ghone1, K M Kumbar, A N Suryakar

  • 1Department of Biochemistry, Dr.V.M.Govt. Medical College, Solapur, India.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

Children with beta thalassemia major exhibit increased oxidative stress due to iron overload from blood transfusions. Their bodies show higher lipid peroxides and lower antioxidant defenses, impacting disease progression.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Hematology

Background:

  • Beta thalassemia major requires frequent blood transfusions.
  • Secondary iron overload from transfusions can cause tissue damage.
  • Understanding oxidative stress in these patients is crucial.

Purpose of the Study:

  • To investigate oxidative stress markers in children with beta thalassemia major.
  • To compare antioxidant status between patients and healthy controls.
  • To elucidate the role of oxidative stress in beta thalassemia major pathogenesis.

Main Methods:

  • Studied 72 children with beta thalassemia major and 72 healthy controls.
  • Measured serum levels of lipid peroxides, iron, TIBC, copper, zinc, and vitamin E.
  • Assessed plasma total antioxidant capacity and erythrocyte superoxide dismutase activity.

Main Results:

  • Patients showed significantly higher lipid peroxide and iron levels (p<0.001).
  • Significantly decreased levels of vitamin E, total antioxidant capacity, and TIBC were observed (p<0.001).
  • Serum zinc was significantly increased (p<0.001), while copper decreased (p<0.001). Erythrocyte superoxide dismutase activity showed no significant change (p>0.05).

Conclusions:

  • Beta thalassemia major patients experience significant oxidative stress.
  • Reduced antioxidant defense mechanisms are implicated in the disease.
  • Iron overload contributes to peroxidative tissue injury in these patients.

Keywords:
AntioxidantsBeta thalassemia majorOxidative stress

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