Related Experiment Video

Updated: May 17, 2026

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure
06:20

Imaging Leukocyte Adhesion to the Vascular Endothelium at High Intraluminal Pressure

Published on: August 23, 2011

Circulating levels of cell adhesion molecules in hypertension

Kavita K Shalia1, Manoj R Mashru, Jagdish B Vasvani

  • 1Sir H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004 India.

Indian Journal of Clinical Biochemistry : IJCB
|October 30, 2012
PubMed

Insights

Newly diagnosed hypertension elevates key inflammatory cell adhesion molecules (CAMs), increasing atherothrombosis risk, especially in younger individuals. This study highlights CAMs

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Biology
  • Hypertension Research

Background:

  • Hypertension is a major risk factor for cardiovascular complications like atherosclerosis and thrombosis.
  • Inflammatory processes, mediated by cell adhesion molecules (CAMs), play a crucial role in these complications.

Purpose of the Study:

  • To investigate the levels of specific soluble CAMs in newly diagnosed hypertensive patients compared to normotensive controls.
  • To explore the relationship between CAM levels and age in hypertensive individuals.

Main Methods:

  • Analysis of soluble endothelial (E)-selectin, platelet (P)-selectin, intercellular CAM-1 (ICAM-1), vascular CAM-1 (VCAM-1), and platelet endothelial CAM-1 (PECAM-1) levels.
  • Enzyme-linked immunosorbent assay (ELISA) used to quantify soluble CAMs.
  • Study included 57 newly diagnosed hypertensive subjects and 57 healthy normotensive controls.

Main Results:

  • Significantly elevated median levels of soluble E-selectin, P-selectin, and ICAM-1 were observed in hypertensive subjects compared to controls.
  • A significant negative correlation was found between soluble P-selectin and age, and between soluble PECAM-1 and age in the hypertension group.

Conclusions:

  • Hypertension is associated with increased expression of certain cell adhesion molecules.
  • Younger hypertensive individuals may face a heightened risk of atherothrombosis due to altered CAM profiles.

Keywords:
Cell adhesion moleculesHypertensionICAM-1PECAM-1SelectinsVCAM-1

More Related Videos

Quantitation of Endothelial Cell Adhesiveness In Vitro10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls10:16

Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

Published on: January 4, 2018

Related Concept Videos

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...