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Related Experiment Video

Updated: May 17, 2026

Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

rTMS over human motor cortex can modulate tremor during movement.

Nigel C Rogasch1, Gabrielle Todd

  • 1Monash Alfred Psychiatry Research Centre, Alfred and Monash University Central Clinical School, Monash University, Melbourne, Vic, Australia.

The European Journal of Neuroscience
|October 31, 2012
PubMed
Summary
This summary is machine-generated.

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Repetitive magnetic brain stimulation (rTMS) over the motor cortex did not reduce tremor size in healthy adults. Instead, inhibitory rTMS unexpectedly increased tremor amplitude, suggesting corticospinal excitability influences tremor magnitude.

Area of Science:

  • Neuroscience
  • Motor Control
  • Neuromodulation

Background:

  • Action tremor significantly impairs daily activities and is a hallmark of various movement disorders.
  • Understanding the neural mechanisms underlying tremor is crucial for developing effective interventions.
  • Repetitive magnetic brain stimulation (rTMS) offers a non-invasive method to modulate cortical activity.

Purpose of the Study:

  • To investigate the efficacy of inhibitory rTMS applied to the motor cortex in reducing action tremor during movement.
  • To explore the relationship between corticospinal excitability and tremor amplitude in healthy individuals.

Main Methods:

  • 26 healthy young adults underwent baseline assessments of corticospinal excitability and action tremor during a finger-tracking task.

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Last Updated: May 17, 2026

Corticospinal Excitability Modulation During Action Observation
12:33

Corticospinal Excitability Modulation During Action Observation

Published on: December 31, 2013

Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment
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Localizing Function-specific Targets for Transcranial Magnetic Stimulation in the Absence of Navigation Equipment

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Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
09:52

Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation

Published on: February 23, 2020

  • Participants received either real or sham inhibitory rTMS over the motor cortex for 10 minutes.
  • Post-intervention, corticospinal excitability and tremor were remeasured using transcranial magnetic stimulation (TMS) and accelerometry.

    • Main Results:

    • Real rTMS significantly reduced corticospinal excitability by approximately 30% compared to sham rTMS (P = 0.022).
    • Contrary to the hypothesis, real rTMS led to a significant ~120% increase in tremor size during movement (P = 0.047).
    • The observed increase in tremor was inversely related to the modulation of corticospinal excitability.

    Conclusions:

    • rTMS over the human motor cortex can modulate action tremor, but not in the hypothesized direction of reduction.
    • Corticospinal excitability levels appear to play a significant role in determining the amplitude of action tremor in healthy adults.
    • These findings highlight the complex interplay between cortical excitability and motor output in tremor generation.