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Endometrial scratching to improve pregnancy rate in couples with unexplained subfertility: a randomized controlled
Ahmed Gibreel1, Ahmed Badawy, Waleed El-Refai
1Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt. ahmedfathgi@yahoo.com
Aim:
The aim of this study was to examine the effect of endometrial scratching in women with unexplained infertility.
Material And Methods:
A randomized controlled trial was conducted in Mansoura University Teaching Hospital and a private practice setting. A total of 105 couples with unexplained infertility were randomly allocated into two groups: group A comprised 54 women who underwent endometrial scratching in the luteal phase of a spontaneous menstrual cycle; and group B included 51 women who underwent a placebo procedure. The main outcome measured was cumulative clinical pregnancy rate after 6 months and miscarriage rate.
Results:
Clinical pregnancy rate was significantly higher in the women experiencing endometrial biopsy than in the control group (25.9% and 9.8%, respectively, P = 0.04). There was no significant difference in miscarriage rate between pregnant women in the endometrial injury group and pregnant women in the control group (12.5% and 16.5%, respectively, P = 0.79).
Conclusions:
Endometrial scratching may improve clinical pregnancy rates in couples with unexplained infertility. Adequately powered studies are mandated to confirm or refute the findings.
