Related Experiment Video

Updated: May 17, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
08:49

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment

Published on: August 2, 2024

Risk factors for delayed graft function in cardiac death donor renal transplants

Ming-Jie Shao1, Qi-Fa Ye, Ying-Zi Ming

  • 1Research Center of Chinese Health Ministry of Transplantation Medicine Engineering and Technology, Third Affiliated Hospital, Central South University, Changsha, Hunan 410013, China.

Chinese Medical Journal
|October 31, 2012
PubMed

Insights

Delayed graft function (DGF) after kidney transplants is linked to donor factors like BMI and ischemia times, and recipient factors such as dialysis duration and HLA mismatch. Identifying these risks can improve transplant outcomes.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Organ Donation

Background:

  • Delayed graft function (DGF) is a significant complication in kidney transplantation, particularly from organ donation after cardiac death (DCD) donors.
  • Understanding center-specific risk factors is crucial for mitigating DGF incidence and enhancing transplant success rates.

Purpose of the Study:

  • To identify and define the specific risk factors associated with DGF following renal transplantation from DCD donors.

Main Methods:

  • A cohort of 56 recipients of DCD kidneys was analyzed between March 2010 and June 2012.
  • Subjects were categorized into immediate graft function (IGF) and DGF groups.
  • Transplantation factors (donor and recipient) and early post-transplant outcomes were compared between groups.

Main Results:

  • Univariate analysis revealed significant associations between DGF and recipient preoperative dialysis time, dialysis type, human leucocyte antigen (HLA) mismatch, and donor factors including cause of brain death, body mass index (BMI), preoperative infection, serum creatinine, norepinephrine use, cardiopulmonary resuscitation (CPR), warm ischemia time (WIT), and cold ischemia time (CIT).
  • Recipients experiencing DGF exhibited longer hospital stays and higher postoperative serum creatinine levels.

Conclusions:

  • Multiple factors contribute to DGF in kidney transplantation.
  • These identified risk factors negatively impact the early post-transplant period, underscoring the need for targeted interventions.
Abstract

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...