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Related Experiment Video

Updated: May 17, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

Transbronchial biopsy is useful in predicting UIP pattern.

Sara Tomassetti1, Alberto Cavazza, Thomas V Colby

  • 1Department of Diseases of the Thorax, Via C, Forlanini, Forlì, FC, 34-47121, Italy.

Respiratory Research
|October 31, 2012
PubMed
Summary
This summary is machine-generated.

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Transbronchial biopsy (TBB) can suggest a usual interstitial pneumonia (UIP) pattern, even with limited findings. However, a negative TBB does not exclude the diagnosis of UIP in interstitial lung disease.

Area of Science:

  • Pulmonology
  • Pathology
  • Radiology

Background:

  • Usual interstitial pneumonia (UIP) is crucial for diagnosing idiopathic pulmonary fibrosis (IPF).
  • The diagnostic value of transbronchial biopsy (TBB) for identifying UIP is not well-established.
  • This study aimed to evaluate the accuracy of TBB in detecting UIP histopathologic criteria.

Purpose of the Study:

  • To assess the accuracy of histopathologic criteria for usual interstitial pneumonia (UIP) in transbronchial biopsy (TBB) specimens.
  • To determine the utility of TBB in predicting a UIP pattern diagnosis.
  • To evaluate TBB's role in the diagnosis of interstitial lung diseases.

Main Methods:

  • Retrospective, blinded, and controlled analysis of TBB specimens.
  • Included 40 established UIP cases and 24 non-UIP interstitial lung disease cases.

Related Experiment Videos

Last Updated: May 17, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
10:19

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

Published on: November 10, 2014

  • Histopathologic evaluation for UIP criteria: patchy interstitial fibrosis, fibroblast foci, honeycomb changes.

    • Main Results:

    • Adequate TBB specimens were obtained in 85% of UIP cases.
    • TBB suggested a UIP pattern in 30% of UIP cases, with sensitivity of 30% and specificity of 100%.
    • Predictive values varied, but the likelihood of identifying UIP increased with specimen size and number.

    Conclusions:

    • Modest UIP findings on TBB can be highly predictive of a UIP pattern.
    • The absence of UIP criteria on TBB does not rule out the diagnosis.
    • TBB can contribute to UIP diagnosis, but its limitations must be considered.