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Carbon dioxide (CO₂) ablation as a remedy for hepatocellular carcinoma
Dong-Yi Liang1, Shi-Chun Zhou, Hongyu Zhou
1College of Power Engineering, Chongqing University, Chongqing, China.
Background/Aims:
The purpose of this research was to investigate the application of carbon dioxide (CO₂) ablation and determine if carbon dioxide plays a role in treating hepatocellular carcinoma.
Methodology:
Twelve mice with subcutaneous xenografts of a hepatocellular cancer cell line were randomly separated into 2 groups. One group underwent CO₂ ablation with their liver tumor in vivo while the other group in vitro, respectively. All mice were killed on day 28. Hematoxylin-eosin (HE) staining was performed on the mice to estimate the pathological change.
Results:
Just after 4 weeks, no significant difference in tumor size was detected between the two groups. The dimensions of the principal tumor varied from 2-3 cm with an average size of 2.2 cm in the greatest dimension. HE staining demonstrated an array of construct damage and necrosis in both groups.
Conclusions:
CO₂ ablation could be an important treatment in the management of cancer.
