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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
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Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

Lung function of infants with congenital lung lesions in the first year of life

Marjolein Spoel1, Kees P van de Ven, Harm A W M Tiddens

  • 1Intensive Care and Department of Pediatric Surgery, Erasmus Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands. m.spoel @ erasmusmc.nl

Neonatology
|October 31, 2012
PubMed

Insights

Surgical resection of congenital lung lesions (CLL) did not negatively impact infant lung function or clinical course in the first year. Long-term follow-up is recommended for all infants with CLL.

Area of Science:

  • Pediatric Pulmonology
  • Neonatal Surgery
  • Respiratory Medicine

Background:

  • Limited data exists on the long-term clinical course and lung function in infants with congenital lung lesions (CLL).
  • Previous studies focused on short-term neonatal outcomes, leaving long-term effects of CLL and surgical intervention unknown.
  • Hypothesized negative impact of surgical resection on clinical course and lung function.

Purpose of the Study:

  • To longitudinally evaluate respiratory symptoms and lung function in infants with CLL during their first year of life.
  • To compare outcomes between infants managed with observation versus those undergoing surgical resection.
  • To assess the impact of surgical intervention on infant respiratory health.

Main Methods:

  • Evaluated 30 infants with CLL at 6 and 12 months of age.
  • Measured functional residual capacity (FRC(p)) using body plethysmography.
  • Assessed maximal expiratory flow (V'(max)FRC) and calculated SD scores for lung function parameters.

Main Results:

  • No significant difference in respiratory symptom prevalence between observation and surgical groups.
  • Similar mean FRC(p) (25.3 vs 27.3) and mean SDS V'(max)FRC (-1.45 vs -1.41) in both groups.
  • Lung function remained stable over the 6-month evaluation period.

Conclusions:

  • Surgical resection of congenital lung lesions (CLL) did not adversely affect clinical course or lung function in the first year of life.
  • Pulmonary follow-up into adulthood is recommended for all CLL patients to identify potential long-term effects.
  • Observation and surgical management appear comparable in the short term for infant CLL.
Abstract

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