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Updated: May 17, 2026

RNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells
18:30

RNA-seq Analysis of Transcriptomes in Thrombin-treated and Control Human Pulmonary Microvascular Endothelial Cells

Published on: February 13, 2013

Thrombin-induced CCN2 expression in human lung fibroblasts requires the c-Src/JAK2/STAT3 pathway

Kua-Jen Bai1, Bing-Chang Chen, Hui-Chen Pai

  • 1College of Medicine, Taipei Medical University, 250 Wu-Hsing St., Taipei, Taiwan.

Journal of Leukocyte Biology
|October 31, 2012
PubMed
Summary

Thrombin activates c-Src, JAK2, and STAT3 signaling pathways to induce CCN2 expression in lung fibroblasts. This study elucidates a novel signaling cascade linking thrombin to fibrotic mediator CCN2 production.

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