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Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: May 17, 2026

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

Brain metastasis: opportunity for drug development?

Matthias Preusser1, Anna S Berghoff, Dirk Schadendorf

  • 1Department of Medicine I and Comprehensive Cancer Center CNS Unit, Medical University of Vienna, Vienna, Austria. Matthias.preusser@meduniwien.ac.at

Current Opinion in Neurology
|October 31, 2012
PubMed
Summary

Novel treatments show promise for brain metastases in melanoma, breast, and lung cancers. Research is advancing drug development for established disease and prevention strategies.

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Last Updated: May 17, 2026

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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis
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Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis

Published on: February 8, 2017

Area of Science:

  • Oncology
  • Neurology
  • Pharmacology

Background:

  • Brain metastases represent a significant clinical challenge with limited therapeutic options.
  • Secondary brain colonization is common in melanoma, breast, and lung cancers.

Purpose of the Study:

  • To review recent advancements in medical research for brain metastases.
  • To explore drug development opportunities for treating and preventing brain metastases.

Main Methods:

  • Review of recent clinical studies and emerging data.
  • Focus on melanoma, breast cancer, and lung cancer brain metastases.

Main Results:

  • BRAF inhibitors and ipilimumab show activity in melanoma brain metastases.
  • HER2-targeting agents like lapatinib are studied for breast cancer brain metastases.
  • Targeted agents show potential for preventing brain metastases in breast and lung cancers.

Conclusions:

  • New drugs are becoming available for specific brain metastasis patients.
  • Promising findings are expected to stimulate further research in brain metastasis treatment.