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Published on: December 6, 2014
Comprehensive report of primary immunodeficiency disorders from a tertiary care center in India
Manisha Madkaikar1, Anju Mishra, Mukesh Desai
1Department of Paediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology, 13th floor, NMS Bldg, KEM Hospital, Parel, Mumbai, 400012, India. madkaikarm@icmr.org.in
Objectives:
There is paucity of data on Primary immunodeficiency disorders (PID) from India. Here we describe the frequency of different primary immunodeficiency disorders, their clinical features and disease complications of 159 patients with PID diagnosed in a tertiary care center from India over the last 3 years.
Methods:
We retrospectively reviewed the records of all the patients identified to have specific PID from 2008 to 2011. The diagnosed patients were classified according to guidelines of International Union of Immunological Society (IUIS) into eight different sub groups.
Results:
The distribution pattern was as follows: diseases of immune dysregulation (29 %), phagocytic defects (29 %), predominant antibody deficiency (13 %), combined T and B cell deficiency (19 %) and other well defined diseases (10 %).
Conclusion:
The distribution pattern of PID varied significantly from those reported by western studies. This study highlights the need for development of more advanced facilities for diagnosis and management of PID in India and also the need for establishing population and hospital based registries.
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