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Updated: May 17, 2026

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment
Published on: August 18, 2023
The immune microenvironment of human tumors: general significance and clinical impact
Wolf-Herman Fridman1, Marie-Caroline Dieu-Nosjean, Franck Pagès
1Institut National de la Santé et de la Recherche Médicale (INSERM), U872, Centre de Recherche des Cordeliers, 15 rue de l'Ecole de Médecine, 75006, Paris, France, herve.fridman@crc.jussieu.fr.
Abstract:
Human cancers grow in a microenvironment of stromal, inflammatory and immunocompetent cells which is variable from tumor to tumor. The characterization of the immune contexture, i.e. the type, density and functional orientation of immunocompetent cells, the presence or absence of tertiary lymphoid structures is a major prognostic factor for patients survival and represent a guide and a target for innovative cancer therapies.
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