Related Experiment Video
Updated: May 17, 2026
04:50
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Management of persistent inflammatory large joint monoarthritis
Rachel Byng-Maddick1, Lukshmy Jeyalingam, Andrew Keat
1Centre for Rheumatology, Department of Medicine, University College London, UK. rachelbm@gmail.com
Clinical Rheumatology
|October 31, 2012
Summary
Persistent inflammatory monoarthritis, a chronic joint inflammation, presents treatment challenges. Current guidelines are lacking, necessitating further research into effective management strategies for this condition.
Area of Science:
- Rheumatology
- Immunology
Background:
- Persistent inflammatory monoarthritis involves chronic inflammation of a single joint, often resistant to standard treatments.
- While some cases self-resolve, others progress to polyarticular disease, posing therapeutic difficulties.
Purpose of the Study:
- To review the current literature on the management of persistent inflammatory monoarthritis.
- To identify treatment gaps and areas requiring further investigation.
Main Methods:
- A literature search was conducted using PubMed with terms including 'monoarthritis', 'chronic synovitis', and 'persistent inflammatory monoarthritis'.
- Inclusion criteria comprised human and animal reports published in English, with references from related articles also reviewed.
Main Results:
- Evidence for traditional disease-modifying antirheumatic drugs (DMARDs) in monoarthritis is limited, with treatment algorithms often adapted from polyarticular disease.
- Intra-articular anti-tumour necrosis factor (TNF) therapies show comparable efficacy to corticosteroids, but systemic anti-TNF use in monoarthritis remains undocumented.
- Synovectomy may reduce recurrence risk, particularly open synovectomy.
Conclusions:
- There is a significant lack of evidence-based guidelines for managing persistent inflammatory monoarthritis.
- Further randomized controlled trials are crucial to establish best practices, balancing treatment efficacy against potential toxicity.
Related Concept Videos
01:21Rheumatic Heart Disease III: Medical Management
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
01:29Inflammatory Bowel Disease IV: Pharmacological Management
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:17Pericarditis III: Medical Management
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
01:22Myocarditis IV: Nursing Management
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...