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Neutralization activity and kinetics of two broad-range human monoclonal IgG1 derived from recombinant Fab fragments

Roberta Antonia Diotti1, Giuseppe Andrea Sautto, Laura Solforosi

  • 1Laboratory of Microbiology and Virology, Universita Vita-Salute San Raffaele, Milano, Italy. diotti.robertaantonia@hsr.it

The New Microbiologica
|October 31, 2012
PubMed

Hepatitis C virus (HCV) is the major cause of chronic liver disease worldwide. There is evidence that neutralizing anti-HCV antibodies may find potential applications in novel prophylactic and therapeutic strategies. This paper describes the very high neutralization activity and unique biological features of two broadly cross-reactive and cross-neutralizing anti-HCV human monoclonal IgG1 derived from human monoclonal recombinant Fab fragments.

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