Contrast-induced nephropathy in patients with ST elevation myocardial infarction treated with primary percutaneous...

Area of Science:

• Cardiology
• Nephrology
• Interventional Cardiology

Background:

• Contrast-induced nephropathy (CIN) is a significant complication following percutaneous coronary intervention (PCI).
• ST-elevation myocardial infarction (STEMI) patients often require urgent PCI, increasing their risk for CIN.
• Predictive markers for CIN in STEMI patients undergoing PCI are crucial for risk stratification and management.

Purpose of the Study:

• To investigate the association between SYNTAX score (SS) and serum uric acid (SUA) levels with CIN in STEMI patients.
• To identify independent predictors of CIN in this patient population.
• To evaluate the potential of SS and SUA as biomarkers for CIN risk.

Main Methods:

• A cohort of 835 STEMI patients undergoing primary PCI was retrospectively analyzed.
• Patients were categorized into groups with and without CIN.
• Logistic regression analysis was employed to determine independent predictors of CIN, including SS, SUA, and diabetes.

Main Results:

• Contrast-induced nephropathy (CIN) was identified in 9.6% of STEMI patients.
• Patients with CIN exhibited significantly higher SYNTAX scores (SS) and serum uric acid (SUA) levels compared to those without CIN (P < .001).
• SS, SUA, and diabetes were confirmed as independent predictors of CIN (P < .05).

Conclusions:

• Elevated SYNTAX scores and serum uric acid levels are significant independent predictors of contrast-induced nephropathy in STEMI patients undergoing primary PCI.
• These findings suggest that SS and SUA can aid in identifying STEMI patients at higher risk for CIN.
• Targeted preventative strategies for CIN may be beneficial for high-risk individuals identified by SS and SUA levels.