Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

H G Holzhütter1, A Colosimo

  • 1Institute of Biochemistry, Humboldt University, Berlin, GDR.

Computer Applications in the Biosciences : CABIOS
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A passive brain-computer interface application for the mental workload assessment on professional air traffic controllers during realistic air traffic control tasks.

Progress in brain research·2016
Same author

A Study on UV Filter Chemicals from Annex VII of European Union Directive 76/768/EEC, in the In Vitro 3T3 NRU Phototoxicity Test.

Alternatives to laboratory animals : ATLA·2015
Same author

Alpha EEG Frontal Asymmetries during Audiovisual Perception in Cochlear Implant Users. A Study with Bilateral and Unilateral Young Users.

Methods of information in medicine·2015
Same author

Evaluation of the workload and drowsiness during car driving by using high resolution EEG activity and neurophysiologic indices.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2015
Same author

The ECVAM Prevalidation Study on the Use of EpiDerm for Skin Corrosivity Testing.

Alternatives to laboratory animals : ATLA·2014
Same author

Modeling function-perfusion behavior in liver lobules including tissue, blood, glucose, lactate and glycogen by use of a coupled two-scale PDE-ODE approach.

Biomechanics and modeling in mechanobiology·2014
Same journal

DCA: an efficient implementation of the divide-and-conquer approach to simultaneous multiple sequence alignment.

Computer applications in the biosciences : CABIOS·1998
Same journal

Two applications to facilitate the viewing of database search result files on the Macintosh.

Computer applications in the biosciences : CABIOS·1998
Same journal

BioWish: a molecular biology command extension to Tcl/Tk.

Computer applications in the biosciences : CABIOS·1998
Same journal

The Sequence Alerting Server--a new WEB server.

Computer applications in the biosciences : CABIOS·1998
Same journal

A software tool for the analysis of mass spectrometric disulfide mapping experiments.

Computer applications in the biosciences : CABIOS·1998
Same journal

SAMBA: hardware accelerator for biological sequence comparison.

Computer applications in the biosciences : CABIOS·1998
See all related articles

A new software package aids biomolecular studies by simulating dynamic models and fitting experimental data. It handles complex equations and compares models, advancing enzyme kinetics and ligand binding research.

Area of Science:

  • Biochemistry and computational biology
  • Enzyme kinetics and ligand binding analysis

Background:

  • Studying biomolecules requires robust computational tools for dynamic modeling and data fitting.
  • Pre-steady and steady-state enzyme kinetics present complex simulation challenges.

Purpose of the Study:

  • To present a versatile software package for simulating and fitting biomolecular models.
  • To address challenges in handling stiff problems and integrating diverse equation types.

Main Methods:

  • Development of a software package for personal computers.
  • Implementation of algorithms for dynamic model simulation and experimental data fitting.
  • Integration of algebraic and differential equations for flexible model definition.

Main Results:

Related Experiment Videos

  • The software package successfully handles stiff problems in biomolecular simulations.
  • It allows for the objective comparison of models with varying complexity.
  • Demonstrated utility through examples in enzyme kinetics and ligand binding.

Conclusions:

  • The presented software package offers an integrated solution for biomolecular simulation and fitting.
  • Its features facilitate advanced analysis of enzyme kinetics and ligand binding processes.
  • The tool enhances the study of biomolecular systems under various conditions.