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Statistical significance of some complex nucleotide combinations: a comparison of DNA models
1Institute of Molecular Genetics, USSR Academy of Sciences, Moscow.
Computer Applications in the Biosciences : CABIOS
|January 1, 1990
Abstract:
DNA is modelled as a sequence of nucleotide runs. This model is shown to provide a more adequate description of the observed frequencies of occurrence of local homopurine-homopyrimidine mirror repeats than the second-order homogeneous Markov chain model. The procedure is described for estimating the statistical significance of the occurrence of some complex nucleotide combinations in DNA.