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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Calcium and phosphate impact cardiovascular risk
Gunnar H Heine1, Masaomi Nangaku, Danilo Fliser
1Internal Medicine IV, Nephrology and Hypertension, Saarland University Medical Center, Homburg D-66421, Germany. gunnar.heine@uks.eu
European Heart Journal
|October 31, 2012
Summary
Altered calcium-phosphate metabolism is a key cardiovascular risk factor, even in those with healthy kidneys. This review examines the role of calcium, phosphate, and regulating hormones in cardiovascular medicine.
Area of Science:
- Cardiovascular Medicine
- Nephrology
- Endocrinology
Background:
- Non-traditional risk factors significantly impact cardiovascular disease (CVD).
- Disordered calcium-phosphate metabolism is a known CVD risk factor in chronic kidney disease patients.
- This metabolism may also affect cardiovascular health in individuals with normal kidney function.
Purpose of the Study:
- To review epidemiological and experimental data on calcium-phosphate metabolism in cardiovascular medicine.
- To explore the role of calcium, phosphate, parathyroid hormone, calcitriol, and fibroblast growth factor 23 in CVD.
Main Methods:
- Literature review of epidemiological studies.
- Literature review of experimental research.
- Synthesis of data on mineral metabolism and cardiovascular outcomes.
Main Results:
- Calcium-phosphate dysregulation is linked to cardiovascular disease progression.
- Key hormones like parathyroid hormone, calcitriol, and FGF23 play crucial roles.
- Evidence suggests these factors are relevant even with preserved renal function.
Conclusions:
- Calcium-phosphate metabolism is an important, often overlooked, factor in cardiovascular health.
- Further research into these non-traditional risk factors may reveal new therapeutic targets for CVD.
- Understanding these hormonal pathways is vital for comprehensive cardiovascular risk assessment.
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