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Updated: May 17, 2026

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Derivation of Human Embryonic Stem Cells by Immunosurgery
Published on: December 13, 2007
Human embryonic stem cell (hESC) and human embryo research
Pediatrics
|October 31, 2012
Summary
Human embryonic stem cell research offers significant potential for treating pediatric diseases. The American Academy of Pediatrics supports continued funding and oversight for this vital research.
Area of Science:
- Pediatric disease research
- Stem cell biology
- Bioethics
Background:
- Human embryonic stem cell (hESC) research is crucial for understanding and treating childhood illnesses.
- Ethical debates surrounding hESC research primarily concern the destruction of preimplantation human embryos for cell sourcing.
- Public opinion largely favors continued hESC research despite ethical considerations.
Purpose of the Study:
- To address the ethical concerns and public perception of human embryonic stem cell research.
- To advocate for continued funding and oversight of hESC research for pediatric applications.
Main Methods:
- Review of ethical considerations regarding the source of human embryonic stem cells.
- Analysis of public opinion on embryonic stem cell research.
- Examination of the potential benefits of hESC research for child health.
Main Results:
- Ethical concerns are focused on embryo source, not stem cell use.
- A significant majority of the public supports continued hESC research.
- hESC research holds substantial promise for improving child health and development.
Conclusions:
- The American Academy of Pediatrics supports continued funding and oversight for human embryo and embryonic stem cell research.
- Continued research is essential for advancing the treatment of pediatric diseases.
- Balancing ethical concerns with potential medical benefits is key to advancing hESC research.
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Embryonic Stem Cells
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Embryonic Stem Cells
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
Stem Cell Culture
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Maintenance of the ES Cell State
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Induced Pluripotent Stem Cells
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Somatic cells are...

