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Related Experiment Video

Updated: May 17, 2026

Subcutaneous Trigeminal Nerve Field Stimulation for Refractory Facial Pain
09:35

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Published on: May 10, 2017

Post-herpetic neuralgia.

Monica Tontodonati1, Tamara Ursini, Ennio Polilli

  • 1Infectious Disease Clinic, Chieti.

International Journal of General Medicine
|October 31, 2012
PubMed
Summary
This summary is machine-generated.

Post-Herpetic Neuralgia (PHN) management requires better standardization. Recent data improve PHN diagnosis and prediction, but treatment remains challenging, necessitating further research and interventions like early antiviral therapy and vaccination.

Keywords:
PHN predictorsPHN preventionPHN treatmentpain relief

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Area of Science:

  • Neurology
  • Pain Management
  • Infectious Diseases

Background:

  • Post-Herpetic Neuralgia (PHN) lacks standardized definition and treatment protocols.
  • Current understanding of PHN diagnosis, prediction, and prevention requires clarification.

Purpose of the Study:

  • To evaluate recent data for improved definition, prediction, treatment, and prevention of PHN.
  • To assess alternative/adjunctive therapies for treatment-resistant PHN.

Main Methods:

  • Systematic reviews, meta-analyses, RCTs, and cohort studies were searched.
  • Databases included PubMed, Cochrane Library, NICE, and DARE.
  • Over 130 relevant papers were selected and analyzed.

Main Results:

  • PHN diagnosis is clinical but enhanced by validated tools and questionnaires.
  • Accurate PHN prediction is possible using clinical and anamnestic variables.
  • Current PHN treatments (antidepressants, gabapentinoids, opioids, topicals) are often unsatisfactory, especially for patients with comorbidities, impacting quality of life.

Conclusions:

  • Improved Post-Herpetic Neuralgia management is crucial.
  • Early antiviral therapy for acute herpes zoster (HZ) and adult HZ vaccination are potential preventive strategies.
  • New therapeutic approaches are needed for refractory PHN.