Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Organization of the Brain

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Specific expansion of motor cortical projections in a singing mouse.

Nature·2026

Same author

Synaptic connectomics by sequencing.

Nature methods·2026

Same author

A lineage-based model of scalable positional information in vertebrate brain development.

Neuron·2026

Same author

Evolution and Development of Neural Circuits.

Cold Spring Harbor perspectives in biology·2025

Same author

Discovery and shaping of decision strategies using adversarial stimuli in rats.

bioRxiv : the preprint server for biology·2025

Same author

Selective expansion of motor cortical projections in the evolution of vocal novelty.

bioRxiv : the preprint server for biology·2024

Same journal

The cell cloud: Adopting systems biology concepts in the era of single-cell immunology.

PLoS biology·2026

Same journal

Disinhibitory signaling enables flexible coding of top-down information in cortical networks.

PLoS biology·2026

Same journal

Correction: Cdc42 interacts with chaperone Ydj1 to enhance its stability and partitioning during asymmetric cell division and aging in yeast.

PLoS biology·2026

Same journal

Towards globally equitable bioinformatics adoption.

PLoS biology·2026

Same journal

The human claustrum supports cognitive networks for externally and internally driven task demands.

PLoS biology·2026

Same journal

Unusual decay: Recombination loss leads to splicing errors in green algae.

PLoS biology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 17, 2026

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Published on: January 17, 2025

Sequencing the connectome.

Anthony M Zador¹, Joshua Dubnau, Hassana K Oyibo

¹Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America. zador@cshl.edu

|October 31, 2012

Summary

This summary is machine-generated.

We developed barcoding of individual neuronal connections (BOINC), a new method to map neural circuits. This DNA sequencing approach enables high-throughput, single-neuron resolution circuit mapping, transforming neuroscience research.

More Related Videos

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

Related Experiment Videos

Last Updated: May 17, 2026

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses

Published on: January 17, 2025

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

Area of Science:

Neuroscience
Molecular Biology
Bioinformatics

Background:

Neural circuit connectivity is crucial for brain function.
Current methods for mapping neural circuits lack high-throughput capabilities and single-neuron precision.

Purpose of the Study:

To introduce a novel, high-throughput method for determining neural circuit connectivity with single-neuron resolution.
To leverage DNA sequencing for scalable circuit mapping.

Main Methods:

Development of barcoding of individual neuronal connections (BOINC).
Utilizing high-throughput DNA sequencing to read out neuronal connection information.
Converting the problem of circuit connectivity into a DNA sequencing readout.

Main Results:

BOINC offers a novel approach to mapping neural circuits.
The method is compatible with the high-throughput nature of DNA sequencing.
Potential for inexpensive, high-resolution circuit mapping.

Conclusions:

BOINC provides a scalable solution for mapping neural circuits at single-neuron resolution.
This technique could revolutionize neuroscience research by enabling comprehensive circuit analysis.
The integration of DNA sequencing offers unprecedented potential for understanding neural connectivity.