Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tellurium-118 as a novel radionuclide for long-term positron emission tomography.

Scientific reports·2026
Same author

Estimation of absorbed doses in computational mouse and human phantoms receiving<sup>229</sup>Th-derived free<sup>225</sup>Ac.

Physics in medicine and biology·2026
Same author

Nanopore direct RNA sequencing reveals METTL2A-mediated m<sup>3</sup>C sites in poly(A) RNA.

Genome research·2025
Same author

Theoretical optimal232Th target thicknesses for225Ac production at proton energies of 70-200 MeV.

Physics in medicine and biology·2025
Same author

Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cells.

Scientific reports·2025
Same author

The MTR4/hnRNPK complex surveils aberrant polyadenylated RNAs with multiple exons.

Nature communications·2024

Related Experiment Video

Updated: May 17, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Long non-coding RNAs in cancer progression.

Keiko Tano1, Nobuyoshi Akimitsu

  • 1Radioisotope Center, The University of Tokyo Tokyo, Japan.

Frontiers in Genetics
|October 31, 2012
PubMed
Summary

Long non-coding RNAs (lncRNAs) are significant in regulating gene expression and cellular processes. Aberrant lncRNA expression is linked to cancer development and progression, highlighting their role in disease.

Area of Science:

  • Genomics
  • Molecular Biology
  • Cancer Research

Background:

  • Large-scale transcriptome analyses reveal widespread transcription across mammalian genomes.
  • Long non-coding RNAs (lncRNAs) are a significant class of transcripts with regulatory functions.
  • Dozens of lncRNAs have been identified as biologically significant molecules.

Purpose of the Study:

  • To review recent findings on the roles of lncRNAs in cancer biology.
  • To highlight the association of lncRNAs with human diseases, particularly cancer.
  • To discuss the impact of aberrant lncRNA expression on cancer progression.

Main Methods:

  • Review of recent scientific literature and transcriptome analyses.
  • Identification and analysis of key lncRNAs involved in cellular regulation.
Keywords:
ANRILHOTAIRMALAT1cancerdiseaselarge non-coding RNA

Related Experiment Videos

Last Updated: May 17, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

  • Examination of studies linking lncRNA expression to cancer development and progression.

    • Main Results:

    • lncRNAs play crucial roles in regulating chromatin remodeling, transcription, and post-transcriptional processing.
    • Several specific lncRNAs (e.g., MALAT1, HOTAIR, ANRIL) are implicated in human diseases, including cancer.
    • Aberrant expression of lncRNAs is frequently observed in cancer and affects disease progression.

    Conclusions:

    • lncRNAs are key regulators in biological processes and disease.
    • Aberrant lncRNA expression significantly influences cancer development and progression.
    • Further research into the molecular mechanisms of lncRNAs in cancer is warranted.