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Published on: September 13, 2018
The expression of pigment epithelium-derived factor in bladder transitional cell carcinoma
Tae Jung Jang1, Sung Woo Kim, Kyung Seop Lee
1Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
Korean Journal of Pathology
|October 31, 2012
Summary
Pigment epithelium-derived factor (PEDF) is lower in bladder cancer, inversely correlating with tumor angiogenesis. Reduced PEDF expression may initiate bladder transitional cell carcinoma (TCC) development.
Area of Science:
- Oncology
- Urology
- Molecular Biology
Background:
- Pigment epithelium-derived factor (PEDF) is a known anti-angiogenic factor.
- Investigating PEDF's role in bladder cancer is crucial for understanding tumor development.
Purpose of the Study:
- To examine the involvement of PEDF in the angiogenesis of bladder transitional cell carcinoma (TCC).
- To assess the relationship between PEDF expression and the biological behavior of TCC.
Main Methods:
- Examined PEDF expression in 99 bladder TCC samples and 10 non-neoplastic tissues.
- Evaluated microvessel density (MVD) as a marker of angiogenesis.
Main Results:
- PEDF expression was significantly lower in TCC (13%) compared to normal urothelium (60%).
- PEDF expression inversely correlated with MVD, with high MVD tumors showing no PEDF expression.
- MVD was significantly higher in high-grade TCC and pT2 tumors.
Conclusions:
- PEDF expression is significantly reduced in bladder TCC and inversely correlated with angiogenesis.
- PEDF expression is not directly related to TCC differentiation or invasion.
- A lack of PEDF expression may be an initial event in the development of bladder TCC.
