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Primary thymic mucinous adenocarcinoma: a case report
Jamshid Abdul-Ghafar1, Suk-Joong Yong, Woocheol Kwon
1Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Korean Journal of Pathology
|October 31, 2012
Summary
Primary thymic mucinous adenocarcinoma is a rare, aggressive cancer. This case report highlights its unique features and emphasizes its recognition as a distinct entity in diagnosing mediastinal carcinomas.
Area of Science:
- Oncology
- Pathology
Background:
- Primary thymic mucinous adenocarcinoma is an extremely rare and aggressive subtype of thymic carcinoma.
- Only nine cases have been reported in the literature to date.
Purpose of the Study:
- To report a case of primary thymic mucinous adenocarcinoma.
- To discuss its histopathological features and diagnostic considerations.
Main Methods:
- Case presentation of a 36-year-old woman with a mediastinal mass.
- Surgical excision and histopathological examination of the mass.
- Immunohistochemical analysis of tumor cells.
Main Results:
- Grossly, the mass was semi-solid with mucin-filled cystic areas.
- Microscopically, it showed infiltrating cords, nests, and glands with mucinous epithelium.
- Immunohistochemistry revealed positivity for CK7, CK20, CD5, CDX-2, and negativity for TTF-1.
Conclusions:
- Primary thymic mucinous adenocarcinoma should be recognized as a distinct histopathological entity.
- It should be considered in the differential diagnosis of mediastinal carcinomas.