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Updated: May 17, 2026

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
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Genome-wide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia

Juan Sandoval1, Holger Heyn, Jesús Méndez-González

  • 1Cancer Epigenetics and Biology Programme, Bellvitge Biomedical Research Institute, L Hospitalet de Llobregat, Barcelona, Catalonia, Spain.

British Journal of Haematology
|November 1, 2012
PubMed
Abstract

No abstract available in PubMed .

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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...