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Updated: May 17, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting
Juan Li1, Lutao Du, Yongmei Yang
1Department of Clinical Laboratory, Qilu Hospital, Shandong University, Jinan, Shandong Province, China.
Abstract:
Emerging evidence has demonstrated that microRNAs (miRNAs) can act as oncogenes or tumor suppressors to participate in cancer development. In this study, we found that miR-429 expression was up-regulated in human colorectal cancer (CRC) tissues, and the high miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis. Functionally, miR-429 overexpression suppressed cell apoptosis by directly targeting SOX2 in HT-29 cells. Taken together, our data suggest for the first time that miR-429 could play an oncogenic role in the cellular processes of CRC and represent a novel prognostic biomarker for CRC.
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