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Updated: May 17, 2026

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder

Published on: August 11, 2015

Deep brain stimulation for treatment-resistant depression.

Alexander S Taghva¹, Donald A Malone, Ali R Rezai

¹Department of Neurological Surgery, Center for Neuromodulation, Ohio State University, Columbus, Ohio, USA; Orange County Neurosurgical Associates, Mission Viejo, California, USA.

World Neurosurgery

|November 1, 2012

Summary

Deep brain stimulation (DBS) shows promise for treatment-resistant depression by modulating brain circuits. Early studies suggest DBS may offer a new therapeutic option for patients unresponsive to conventional treatments.

Keywords:

ALIC Anterior limb of internal capsule CSPTC Corticostriatopallidothalamocortical DBS Deep brain stimulation Depression MDD Major depressive disorder NAcc Neuromodulation Nucleus accumbens OCD Obsessive-compulsive disorder SGC Subgenual cingulate gyrus TRD Treatment-resistant depression VC VS Ventral capsule Ventral striatum

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Area of Science:

Neuroscience
Psychiatry
Neurosurgery

Background:

Major depressive disorder (MDD) is a leading cause of global disability.
A significant portion of patients do not respond to existing treatments.
Deep brain stimulation (DBS) modulates neural circuits implicated in neuropsychiatric disorders.

Observation:

The subgenual cingulate gyrus and ventral capsule/ventral striatum are primary targets for DBS in treatment-resistant depression.
Preliminary data from DBS studies in these regions are encouraging.

Findings:

DBS involves the modulation of corticostriatopallidothalamocortical circuits.
Early research indicates potential efficacy for DBS in refractory depression.

Implications:

DBS may emerge as a viable therapeutic strategy for treatment-resistant depression.
Further research is warranted due to the substantial burden of MDD.