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Updated: May 17, 2026

A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
Coronary artery bypass graft surgery during heart transplantation
Carlos S Pinto1, David Prieto, Manuel J Antunes
1Faculty of Medicine, Centre of Cardiothoracic Surgery, University Hospital, Coimbra, Portugal.
Insights
A donor heart for transplant had unexpected atherosclerosis in the anterior descending artery. Surgeons used the patient
Area of Science:
- Cardiovascular Surgery
- Organ Transplantation
- Cardiology
Background:
- Heart transplantation is a life-saving procedure for end-stage heart failure.
- Coronary artery bypass graft (CABG) surgery is a common cardiac procedure.
- Donor heart evaluation is critical to ensure graft viability.
Observation:
- During bench preparation for heart transplantation, a significant atherosclerotic lesion was palpated in the donor heart's anterior descending artery.
- This lesion was not identified during the pre-harvesting screening of the donor.
- The patient had a history of prior CABG surgery with a patent internal thoracic artery graft.
Findings:
- The presence of undetected atherosclerosis in a donor heart necessitated intraoperative decision-making.
- The patient's own patent internal thoracic artery was successfully utilized for bypass grafting to the affected coronary artery.
- This approach circumvented the need for immediate intervention on the donor heart's vasculature.
Implications:
- Highlights the importance of thorough intraoperative donor heart assessment beyond standard pre-transplant screening.
- Demonstrates the feasibility of utilizing autologous grafts (patient's own vessels) during transplantation when donor grafts are compromised.
- Suggests a potential strategy for managing unexpected coronary artery disease in donor hearts, optimizing transplant outcomes.
Abstract:
We report the case of a patient who was submitted to coronary artery bypass graft surgery (CABG) during heart transplant as, during bench exploration, the donor heart presented a palpable atherosclerotic lesion in the anterior descending artery, not detected before harvesting. The patent internal thoracic artery from a previous CABG was used.

