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Anti‑livin antibodies in Hashimoto thyroiditis
Aleksandra Baumann-Antczak1, Jerzy Kosowicz, Hanna Zamysłowska
1Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznań, Poland.
Polskie Archiwum Medycyny Wewnetrznej
|November 1, 2012
Summary
Anti-livin antibodies, previously linked to cancers, are also prevalent in Hashimoto thyroiditis patients. This suggests these antibodies are markers of broader autoimmune processes, not just malignancy.
Area of Science:
- Immunology
- Endocrinology
- Oncology
Background:
- Livin is an apoptosis inhibitor overexpressed in various cancers.
- Anti-livin antibodies are found in some malignant conditions.
- Hashimoto thyroiditis involves significant thyrocyte apoptosis.
Purpose of the Study:
- To investigate the presence of anti-livin antibodies in Hashimoto thyroiditis.
- To determine if anti-livin antibodies are associated with this autoimmune thyroid disease.
Main Methods:
- Radioimmunoassay was used to detect anti-livin antibodies.
- Study included 65 women with Hashimoto thyroiditis and 40 healthy controls.
- Patients had hypothyroidism and high antithyroid peroxidase antibodies.
Main Results:
- Anti-livin antibodies were detected in 26.8% of Hashimoto thyroiditis patients.
- Borderline levels were found in 4.6% of patients.
- Only 2.5% of controls showed positive antibody levels (P <0.0001).
Conclusions:
- Anti-livin antibodies are present in Hashimoto thyroiditis, indicating a broader autoimmune involvement.
- These antibodies are not exclusive markers for malignancy and appear in autoimmune diseases.
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