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Acute antioxidant pre-treatment attenuates endothelial microparticle release after decompression
Bryna Cr Chrismas1, Adrian W Midgley, Lee Taylor
1Postgraduate Student, Department of Sport, Health and Exercise Science, The University of Hull.
Diving and Hyperbaric Medicine
|November 1, 2012
Summary
Antioxidant pre-treatment significantly reduced CD105 microparticle release after diving, suggesting it may protect endothelial function in divers. This intervention shows promise for dive safety.
Area of Science:
- Physiology
- Marine Biology
- Biochemistry
Background:
- Diving induces hyperbaric and hyperoxic stress, affecting oxidative stress and endothelial function.
- Endothelial microparticles (MPs), particularly CD105 MPs, are emerging in vivo markers of endothelial health.
- Increased CD105 MPs post-dive correlate with diminished endothelial function.
Purpose of the Study:
- To investigate if antioxidant (AOX) pre-treatment can mitigate the rise in CD105 MPs following a simulated dive.
- To assess the efficacy of AOX in preserving endothelial function markers in divers.
Main Methods:
- Five healthy, pressure-naive males underwent two simulated dives (18m for 80 min) breathing compressed air.
- Subjects received either a placebo or an antioxidant supplement (vitamins C, E, selenium, beta-carotene) 2 hours pre-dive.
- Measurements included CD105 MPs, total antioxidant capacity (TAC), and thiobarbituric reactive substances (TBARS) at various dive stages.
Main Results:
- The control dive showed a significant increase in CD105 MPs immediately post-dive compared to baseline and at-depth values.
- Antioxidant pre-treatment significantly attenuated the post-dive increase in CD105 MPs (P = 0.002).
- No significant changes in TBARS or TAC were observed in either condition.
Conclusions:
- Antioxidant pre-treatment effectively reduced CD105 MP release post-dive.
- These findings suggest AOX may serve as an endothelial pre-conditioner for divers.
- Further research is warranted to confirm AOX's protective role in diving activities.
