S100B and its relation to intravascular bubbles following decompression
Marianne B Havnes1, Astrid Hjelde, Alf O Brubakk
1Doctoral student, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrres gt. 9, N-7489 Trondheim, Norway, Phone: +47-(0) 72-828043,
Introduction:
When neurological damage occurs in divers, it is considered to be caused by gas bubbles. Entrapment of these bubbles may lead to cellular injury and cerebral oedema. S100B is a protein biomarker that is released in CNS injuries and the concentration is related to the amount of brain damage.
Methods:
A total of 27 rats were randomly assigned to one of three groups. Group I served as controls (n = 9). Group II (n = 7) underwent a simulated dive to 400 kPa and Group III to 700 kPa (n = 11). In groups II and III, venous gas bubble scores were evaluated by ultrasound during the first hour after surfacing. The amount of S100B in serum after the dives was tested using a commercial ELISA kit. Bubble grades were compared to S100B protein concentrations.
Results:
The average level of S100B was significantly higher in rats compressed to 700 kPa compared to the control rats, (P = 0.038) and the rats compressed to 400 kPa, (P = 0.003). There was no difference in S100B concentration between groups I and II. Following the dive to 700 kPa, there were significantly higher bubble grades observed than following the dive to 400 kPa (P = 0.001).
Conclusion:
The correlation between bubble grade and an increase in serum protein level of S100B indicates that this protein may be useful as a biomarker for neurological damage caused by decompression.
More Related Videos
05:31Imaging and Quantification of the Area of Fast-Moving Microbubbles Using a High-Speed Camera and Image Analysis
Published on: September 5, 2020
08:02A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
Published on: July 16, 2020
Related Concept Videos
01:13Excess Pressure Inside a Drop and a Bubble
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...