Related Experiment Video
Updated: May 17, 2026
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
Mean platelet volume on admission is associated with further left ventricular functions in primary PTCA patients
1Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey. drzeydin@gmail.co
Insights
In ST elevation myocardial infarction (STEMI) patients, higher mean platelet volume (MPV) on admission indicates poorer left ventricular systolic function after percutaneous coronary intervention. This finding highlights MPV as a potential biomarker for adverse outcomes in STEMI.
Area of Science:
- Cardiology
- Hematology
- Biomarkers
Background:
- Mean platelet volume (MPV) is linked to artery patency in ST elevation myocardial infarction (STEMI) patients.
- The association between MPV and left ventricular (LV) function in anterior STEMI patients post-percutaneous coronary intervention (PCI) remains unclear.
Purpose of the Study:
- To investigate the relationship between admission MPV and LV systolic function in anterior STEMI patients undergoing primary PCI.
Main Methods:
- The study included 97 anterior STEMI patients treated with primary PCI.
- MPV was measured on admission.
- Left ventricular ejection fraction (LVEF) was assessed using echocardiography within 3 days of discharge.
- Patients were categorized into two groups: systolic dysfunction (LVEF < 50%) and normal systolic function (LVEF > 50%).
Main Results:
- Patients with systolic dysfunction (n=61) had a significantly higher MPV (9.5±1.1 fL) compared to those with normal function (n=36, 8.8±0.8 fL; p=0.001).
- Significant differences were observed in Troponin I levels and white blood cell counts between the groups.
Conclusions:
- Increased MPV on admission is associated with impaired left ventricular systolic function in anterior STEMI patients treated with PCI.
- MPV may serve as a predictive biomarker for LV dysfunction post-PCI in STEMI.
Aim:
In ST elevation myocardial infarction (STEMI) patients, mean platelet volume (MPV) is associated with infarct related artery patency both before and after reperfusion. In anterior STEMI patients successfully treated with primary percutaneous coronary intervention (PCI), the relationship between left ventricular (LV) function and MPV on admission is unknown.
Methods:
97 anterior STEMI patients successfully revascularizated with PCI between January 2010 and February 2011 are included. MPV on admission is recorded. All patients underwent transthoracic echocardiography within 3 days or before discharge. Patients were divided into two groups according to left ventricular ejection fraction (LVEF), as systolic dysfunction (LVEF < 50%, 1st group) and normal systolic functions (LVEF > 50%, 2nd group). The 1st group included 61 (47 males) patients and the 2nd group included 36 (35 males) patients.
Results:
MPV was; 9.5+/-1.1 femtoliter (fL) in the 1st and 8.8+/-0.8 fL in the second group. The difference between the groups was significant (p = 0.001). There was a significant difference in the Troponin I levels and white blood cell (WBC) counts on admission between two groups (30+/-29 vs 12.2+/-15.1 ng/mL, p = 0.001 and 12.3+/-3.8 vs 10.6+/-3.4 counts ×109/L, p = 0.027, respectively).
Conclusions:
In anterior STEMI patients treated with percutaneous coronary intervention, increased MPV on admission is associated with impairment in left ventricular systolic function.
Related Concept Videos
01:22Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:22Mitral Stenosis I: Introduction