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Related Concept Videos

Drug Elimination by Renal Route: Tubular Reabsorption01:22

Drug Elimination by Renal Route: Tubular Reabsorption

During the process of renal excretion, as the glomerular filtrate progresses to the distal convoluted tubule (DCT), drugs that are highly permeable, lipophilic, and nonionized undergo passive reabsorption from the tubular fluid into the surrounding peritubular capillaries. This reabsorption process restricts their elimination through the kidneys. However, the majority of drugs are either weak acids or weak bases, and their ionization level is dependent on pH. By altering the pH of urine, the...
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Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
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Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
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Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
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Related Experiment Video

Updated: May 17, 2026

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
10:19

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Published on: August 9, 2012

Illicit ketamine and its bladder consequences: is it irreversible?

Rozh Jalil1, Suresh Gupta

  • 1Department of Surgery and Cancer, Imperial College London, London, UK. rozh6@yahoo.com

BMJ Case Reports
|November 1, 2012
PubMed
Summary

Ketamine abuse can cause severe bladder damage, a condition known as ketamine bladder syndrome. This condition leads to ulcerative cystitis and significant urinary symptoms, potentially causing irreversible harm.

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Published on: July 18, 2025

Area of Science:

  • Urology
  • Toxicology
  • Nephrology

Background:

  • Ketamine abuse is a growing public health concern.
  • Emerging evidence suggests a link between ketamine use and urinary tract pathology.
  • The term 'ketamine bladder' has been proposed to describe this clinical entity.

Observation:

  • Four young patients presented with severe lower urinary tract symptoms.
  • These patients were referred to a urology unit for evaluation.
  • Ulcerative cystitis was diagnosed in all four patients.

Findings:

  • The diagnosed ulcerative cystitis was found to be secondary to ketamine abuse.
  • The clinical presentation included significant lower urinary tract symptoms.
  • The underlying pathophysiology of ketamine-induced cystitis remains unclear.

Implications:

  • Ketamine abuse can lead to severe and potentially irreversible urinary system damage.
  • Early recognition and diagnosis of ketamine bladder are crucial.
  • Current treatment strategies for ketamine bladder are primarily symptomatic.