Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Professional society recommended interventions for enhanced recovery after cesarean delivery in the United States: a multidisciplinary Delphi study.

International journal of obstetric anesthesia·2025

Same author

Topical delivery of mupirocin calcium nanostructured lipid carriers using a full-thickness excision wound healing model.

Journal of wound care·2023

Same author

Complete Heparin Reversal by Protamine during Off-Pump Coronary Artery Bypass Surgery (OPCAB): A Necessity or Myth?

Mymensingh medical journal : MMJ·2023

Same author

Toxicological effects of thimerosal on rat kidney: a histological and biochemical study.

Brazilian journal of biology = Revista brasleira de biologia·2021

Same author

Mitigation of cisplatin induced nephrotoxicity by casticin in male albino rats.

Brazilian journal of biology = Revista brasleira de biologia·2021

Same author

Enterotoxigenic methicillin resistant Staphylococcus aureus contamination in salted fish from Gwadar Balochistan.

Brazilian journal of biology = Revista brasleira de biologia·2021

Search research articles

Related Experiment Video

Updated: May 17, 2026

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Inhalational system for Etoposide liposomes: formulation development and in vitro deposition.

J J Parmar¹, D J Singh, A A Lohade

¹Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai-400 098, India.

Indian Journal of Pharmaceutical Sciences

|November 1, 2012

Summary

Freeze-dried etoposide liposomes offer improved pulmonary delivery for lung cancer treatment. This formulation enhances stability and fine particle fraction, addressing concerns with conventional etoposide administration.

Keywords:

Etoposide inhalation liposome pulmonary delivery twin stage impinger

More Related Videos

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Related Experiment Videos

Last Updated: May 17, 2026

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals

Published on: March 30, 2017

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Preparation, Administration, and Assessment of In Vivo Tissue-Specific Cellular Uptake of Fluorescent Dye-Labeled Liposomes

Published on: July 30, 2020

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Nanotechnology

Background:

Etoposide is a key chemotherapy agent for non-small cell lung cancer.
Frequent dosing and adverse effects limit etoposide efficacy.
Liposomal systems are promising for pulmonary drug delivery due to lung surfactant compatibility.

Purpose of the Study:

To develop and characterize a liposomal pulmonary delivery system for etoposide.
To optimize liposome formulation for enhanced entrapment efficiency and particle size.
To improve the shelf-life and stability of etoposide liposomes through freeze-drying.

Main Methods:

Liposomes prepared using the film hydration method.
Formulation optimization for entrapment efficiency and particle size.
Freeze-drying with trehalose as a cryoprotectant for enhanced stability.
Characterization included entrapment efficiency, particle size, surface topography, and in vitro drug release.
Fine particle fraction assessed using a twin-stage impinger.

Main Results:

Optimized etoposide liposomes were successfully prepared.
Freeze-dried liposomes demonstrated superior fine particle fraction and drug content.
Stability studies showed freeze-dried liposomes maintained integrity over six months at various temperatures.
In vitro release studies were conducted in simulated lung fluid at 37°C, pH 7.4.

Conclusions:

Freeze-dried liposomal etoposide offers a stable and effective pulmonary delivery system.
This approach can potentially improve lung cancer treatment by optimizing etoposide administration.
The enhanced stability and respirable characteristics address limitations of conventional etoposide therapy.