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Related Experiment Video

Updated: May 17, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

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ATT- A Double Edged Sword?

D Gude¹, D P Bansal

¹Department of Internal Medicine, Medwin Hospital, Nampally, Hyderabad-500 001, India.

Indian Journal of Pharmaceutical Sciences

|November 1, 2012

Summary

This summary is machine-generated.

Antitubercular therapy (ATT) can cause liver damage (hepatotoxicity), which is often underestimated. This case highlights the risks and reviews strategies to prevent ATT-induced liver injury.

Keywords:

Acute liver failure antitubercular therapy hepatotoxicity

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Area of Science:

Hepatology
Pharmacology
Infectious Diseases

Background:

Antitubercular therapy (ATT)-induced hepatotoxicity is a significant clinical concern.
The condition is frequently overlooked despite its potential for serious morbidity.
Risk factors can exacerbate the adverse effects of ATT.

Purpose of the Study:

To present a case illustrating detrimental ATT-induced hepatotoxicity.
To review existing literature on ATT hepatotoxicity.
To explore potential preventive strategies for managing liver injury during ATT.

Main Methods:

Case report presentation.
Comprehensive literature review on antitubercular therapy and hepatotoxicity.
Analysis of risk factors and preventive measures.

Main Results:

The presented case demonstrated severe liver injury attributed to ATT.
Literature review confirmed a range of risk factors contributing to ATT hepatotoxicity.
Various preventive strategies were identified and discussed.

Conclusions:

ATT-induced hepatotoxicity requires greater clinical attention and proactive management.
Identifying and mitigating risk factors are crucial for patient safety during tuberculosis treatment.
Further research into effective preventive strategies is warranted to minimize liver damage.